PRTA PEER ANALYSIS

Prothena Corporation plc — metric-by-metric comparison with peers and the industry median

PRTAProthena Corporation plc

🇺🇸 USA · NASDAQ · Healthcare · Biotechnology

Value it Duel

Overall Profile & Returns

· Biotechnology

Position Within Industry

0 = weak quartile, 100 = strong quartile

PRTAIndustry median

Scores normalize each metric against industry quartiles (p25–p75); direction is inverted for lower-is-better metrics.

Return Comparison

1-Year

Split-adjusted

Year-to-Date (YTD)

Key Metric Comparison

P/E

Lower is better

ROE

Higher is better

Net Margin

Higher is better

Revenue Growth

Higher is better

All Metrics

Valuation
Metric	PRTA	MSB	TLX	RTALB	Ind. Median
P/E	—	—	—	4.89	17.91
P/B	1.68	—	6.37	0.61●	3.51
EV/EBITDA	—	—	120.14	74.61●	14.82
P/S	9.05	31.61	3.24●	6.67	10.89

Financial Health
Metric	PRTA	MSB	TLX	RTALB	Ind. Median
Current Ratio	10.43●	—	1.43	1.21	5.90
Debt/Equity	2.4%	—	112.3%	1.2%●	10.9%
NetDebt/EBITDA	4.31	—	13.13	0.90●	1.15

Profitability
Metric	PRTA	MSB	TLX	RTALB	Ind. Median
Net Margin	-260.9%	-115.3%	-0.9%	136.3%●	-125.7%
ROE	-40.3%	-11.3%	-1.8%	15.1%●	-47.5%
ROA	-35.8%	-8.6%	-0.7%	13.1%●	-35.8%
EBITDA Margin	-129.0%	-76.6%	3.0%	9.0%●	-105.8%

Growth + Dividend
Metric	PRTA	MSB	TLX	RTALB	Ind. Median
Rev. Growth	-58.0%	410.4%●	56.3%	24.0%	5.1%
NI Growth	—	—	—	134.0%	12.1%
Div. Yield	—	0.0%●	—	0.0%●	0.2%
Payout	—	0.0%	—	0.0%	0.0%

Valuation
Metric	PRTA	AURA	XFOR	ARVN	ALLO	ZURA	Ind. Median
P/E	—	—	—	—	—	—	17.91
P/B	1.68	4.87	3.10	1.39●	1.79	2.67	3.51
EV/EBITDA	—	—	—	—	—	—	14.82
P/S	9.05	—	57.86	6.01●	—	—	10.89

Financial Health
Metric	PRTA	AURA	XFOR	ARVN	ALLO	ZURA	Ind. Median
Current Ratio	10.43	7.09	10.18	5.44	9.65	19.33●	5.90
Debt/Equity	2.4%	15.8%	45.9%	2.2%●	29.1%	—	10.9%
NetDebt/EBITDA	4.31	0.88●	1.74	2.80	1.16	—	1.15

Profitability
Metric	PRTA	AURA	XFOR	ARVN	ALLO	ZURA	Ind. Median
Net Margin	-260.9%	—	-1,106.3%	-247.5%●	—	—	-125.7%
ROE	-40.3%●	-95.6%	-104.2%	-42.3%	-52.3%	-42.5%	-47.5%
ROA	-35.8%	-76.7%	-49.8%	-26.8%●	-38.4%	-37.6%	-35.8%
EBITDA Margin	-129.0%●	—	-996.8%	-242.2%	—	—	-105.8%

Growth + Dividend
Metric	PRTA	AURA	XFOR	ARVN	ALLO	ZURA	Ind. Median
Rev. Growth	-58.0%●	-100.0%	-71.3%	-79.1%	—	-100.0%	5.1%
NI Growth	—	—	—	—	—	—	12.1%
Div. Yield	—	—	—	—	—	—	0.2%
Payout	—	—	—	—	—	—	0.0%

The green dot marks the best value in the group given the metric direction (higher/lower is better). All metrics use trailing-twelve-month (TTM) data.

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Data on this page refreshes once per day. Price data as of Jul 2, 26. This content is for informational purposes only and is not investment advice.