OBIO PEER ANALYSIS

Orchestra BioMed Holdings Inc. — metric-by-metric comparison with peers and the industry median

OBIOOrchestra BioMed Holdings Inc.

🇺🇸 USA · NASDAQ · Healthcare · Biotechnology

Value it Duel

Overall Profile & Returns

· Biotechnology

Position Within Industry

0 = weak quartile, 100 = strong quartile

OBIOIndustry median

Scores normalize each metric against industry quartiles (p25–p75); direction is inverted for lower-is-better metrics.

Return Comparison

1-Year

Split-adjusted

Year-to-Date (YTD)

Key Metric Comparison

P/E

Lower is better

ROE

Higher is better

Net Margin

Higher is better

Revenue Growth

Higher is better

All Metrics

Valuation
Metric	OBIO	RTALB	MSB	TLX	Ind. Median
P/E	—	4.89	—	—	17.81
P/B	3.07	0.61●	—	6.56	3.49
EV/EBITDA	—	74.61●	—	123.31	14.92
P/S	4.79	6.67	31.91	3.34●	10.89

Financial Health
Metric	OBIO	RTALB	MSB	TLX	Ind. Median
Current Ratio	7.03●	1.21	—	1.43	5.90
Debt/Equity	66.0%	1.2%●	—	112.3%	10.9%
NetDebt/EBITDA	1.15	0.90●	—	13.13	1.15

Profitability
Metric	OBIO	RTALB	MSB	TLX	Ind. Median
Net Margin	-167.0%	136.3%●	-115.3%	-0.9%	-125.7%
ROE	-161.1%	15.1%●	-11.3%	-1.8%	-47.5%
ROA	-68.4%	13.1%●	-8.6%	-0.7%	-35.8%
EBITDA Margin	-161.1%	9.0%●	-76.6%	3.0%	-105.8%

Growth + Dividend
Metric	OBIO	RTALB	MSB	TLX	Ind. Median
Rev. Growth	1,033.9%●	24.0%	410.4%	56.3%	5.1%
NI Growth	—	134.0%	—	—	12.1%
Div. Yield	—	0.0%●	0.0%●	—	0.2%
Payout	—	0.0%	0.0%	—	0.0%

Valuation
Metric	OBIO	ATRA	CRBU	HUMA	ALDX	CUE	Ind. Median
P/E	—	—	—	—	—	—	17.81
P/B	3.07	-4.11●	1.72	13.12	3.26	7.23	3.49
EV/EBITDA	—	—	—	—	—	—	14.92
P/S	4.79	6.62	15.66	75.63	—	4.77●	10.89

Financial Health
Metric	OBIO	ATRA	CRBU	HUMA	ALDX	CUE	Ind. Median
Current Ratio	7.03●	2.16	6.22	3.93	2.72	3.57	5.90
Debt/Equity	66.0%	-27.0%●	26.4%	566.9%	36.8%	15.9%	10.9%
NetDebt/EBITDA	1.15	-0.32●	0.81	-0.22	1.96	0.82	1.15

Profitability
Metric	OBIO	ATRA	CRBU	HUMA	ALDX	CUE	Ind. Median
Net Margin	-167.0%	-40.9%●	-1,189.1%	-4,840.8%	—	-59.6%	-125.7%
ROE	-161.1%	—	-83.5%	-409.5%	-51.8%●	-138.5%	-47.5%
ROA	-68.4%	-23.1%●	-63.0%	-71.5%	-34.3%	-73.5%	-35.8%
EBITDA Margin	-161.1%	-23.7%●	-999.5%	-3,956.7%	—	-48.4%	-105.8%

Growth + Dividend
Metric	OBIO	ATRA	CRBU	HUMA	ALDX	CUE	Ind. Median
Rev. Growth	1,033.9%●	-88.4%	13.0%	-74.0%	-100.0%	309.6%	5.1%
NI Growth	—	—	—	—	—	—	12.1%
Div. Yield	—	—	—	0.0%	—	—	0.2%
Payout	—	—	—	0.0%	—	—	0.0%

The green dot marks the best value in the group given the metric direction (higher/lower is better). All metrics use trailing-twelve-month (TTM) data.

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Data on this page refreshes once per day. Price data as of Jul 6, 26. This content is for informational purposes only and is not investment advice.