KPTI PEER ANALYSIS

Karyopharm Therapeutics Inc — metric-by-metric comparison with peers and the industry median

KPTIKaryopharm Therapeutics Inc

🇺🇸 USA · NASDAQ · Healthcare · Biotechnology

Value it Duel

Overall Profile & Returns

· Biotechnology

Position Within Industry

0 = weak quartile, 100 = strong quartile

KPTIIndustry median

Scores normalize each metric against industry quartiles (p25–p75); direction is inverted for lower-is-better metrics.

Return Comparison

1-Year

Split-adjusted

Year-to-Date (YTD)

Key Metric Comparison

P/E

Lower is better

ROE

Higher is better

Net Margin

Higher is better

Revenue Growth

Higher is better

All Metrics

Valuation
Metric	KPTI	MSB	RTALB	TLX	Ind. Median
P/E	—	—	4.78	—	18.06
P/B	-0.94●	—	0.59	6.38	3.62
EV/EBITDA	—	—	72.98●	120.20	15.13
P/S	1.64●	31.30	6.52	3.24	10.65

Financial Health
Metric	KPTI	MSB	RTALB	TLX	Ind. Median
Current Ratio	1.08	—	1.21	1.43●	5.90
Debt/Equity	-86.9%●	—	1.2%	112.3%	10.9%
NetDebt/EBITDA	-0.95●	—	0.90	13.13	1.15

Profitability
Metric	KPTI	MSB	RTALB	TLX	Ind. Median
Net Margin	-129.0%	-115.3%	136.3%●	-0.9%	-125.7%
ROE	—	-11.3%	15.1%●	-1.8%	-47.5%
ROA	-150.5%	-8.6%	13.1%●	-0.7%	-35.8%
EBITDA Margin	-97.9%	-76.6%	9.0%●	3.0%	-105.8%

Growth + Dividend
Metric	KPTI	MSB	RTALB	TLX	Ind. Median
Rev. Growth	6.3%	410.4%●	24.0%	56.3%	5.1%
NI Growth	—	—	134.0%	—	12.1%
Div. Yield	—	0.0%●	0.0%●	—	0.2%
Payout	—	0.0%	0.0%	—	0.0%

Valuation
Metric	KPTI	NKTX	RNA	AVXL	IMRX	ALEC	Ind. Median
P/E	—	—	—	—	—	—	18.06
P/B	-0.94●	0.88	0.97	1.91	0.00	20.56	3.62
EV/EBITDA	—	—	—	—	—	—	15.13
P/S	1.64●	—	6.15	—	—	11.59	10.65

Financial Health
Metric	KPTI	NKTX	RNA	AVXL	IMRX	ALEC	Ind. Median
Current Ratio	1.08	12.96	13.04	20.87	32.45●	5.25	5.90
Debt/Equity	-86.9%●	26.2%	1.1%	—	1.8%	332.8%	10.9%
NetDebt/EBITDA	-0.95	1.71	0.65	—	-60.72●	1.48	1.15

Profitability
Metric	KPTI	NKTX	RNA	AVXL	IMRX	ALEC	Ind. Median
Net Margin	-129.0%●	—	-1,076.9%	—	—	-680.8%	-125.7%
ROE	—	-30.1%	-50.7%	-33.6%	-0.1%●	-238.9%	-47.5%
ROA	-150.5%	-23.7%	-45.3%	-31.1%	-0.1%●	-38.7%	-35.8%
EBITDA Margin	-97.9%●	—	-1,108.5%	—	—	-632.1%	-105.8%

Growth + Dividend
Metric	KPTI	NKTX	RNA	AVXL	IMRX	ALEC	Ind. Median
Rev. Growth	6.3%	-100.0%	312.4%●	—	-100.0%	-79.2%	5.1%
NI Growth	—	—	—	—	—	—	12.1%
Div. Yield	—	—	—	—	—	—	0.2%
Payout	—	—	—	—	—	—	0.0%

The green dot marks the best value in the group given the metric direction (higher/lower is better). All metrics use trailing-twelve-month (TTM) data.

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Data on this page refreshes once per day. Price data as of Jul 7, 26. This content is for informational purposes only and is not investment advice.