IONS PEER ANALYSIS

Ionis Pharmaceuticals Inc — metric-by-metric comparison with peers and the industry median

IONSIonis Pharmaceuticals Inc

🇺🇸 USA · NASDAQ · Healthcare · Biotechnology

Value it Duel

Overall Profile & Returns

· Biotechnology

Position Within Industry

0 = weak quartile, 100 = strong quartile

IONSIndustry median

Scores normalize each metric against industry quartiles (p25–p75); direction is inverted for lower-is-better metrics.

Return Comparison

1-Year

Split-adjusted

Year-to-Date (YTD)

Key Metric Comparison

P/E

Lower is better

ROE

Higher is better

Net Margin

Higher is better

Revenue Growth

Higher is better

All Metrics

Valuation
Metric	IONS	CSL	TLX	MSB	Ind. Median
P/E	—	29.44	—	—	17.91
P/B	27.24	2.20●	6.37	—	3.51
EV/EBITDA	2.95●	10.21	120.14	—	14.82
P/S	12.65	2.62●	3.24	31.61	10.89

Financial Health
Metric	IONS	CSL	TLX	MSB	Ind. Median
Current Ratio	4.10●	2.57	1.43	—	5.90
Debt/Equity	415.3%	67.4%●	112.3%	—	10.9%
NetDebt/EBITDA	0.03●	2.22	13.13	—	1.15

Profitability
Metric	IONS	CSL	TLX	MSB	Ind. Median
Net Margin	-30.9%	9.2%●	-0.9%	-115.3%	-125.7%
ROE	-67.5%	7.7%●	-1.8%	-11.3%	-47.5%
ROA	-10.4%	3.8%●	-0.7%	-8.6%	-35.8%
EBITDA Margin	433.5%●	32.8%	3.0%	-76.6%	-105.8%

Growth + Dividend
Metric	IONS	CSL	TLX	MSB	Ind. Median
Rev. Growth	47.5%	4.8%	56.3%	410.4%●	5.1%
NI Growth	—	-39.4%	—	—	12.1%
Div. Yield	0.2%	2.5%●	—	0.0%	0.2%
Payout	-6.7%	103.1%	—	0.0%	0.0%

Valuation
Metric	IONS	AXSM	EXEL	ARWR	BBIO	MDGL	Ind. Median
P/E	—	—	17.91	—	—	—	17.91
P/B	27.24	229.14	7.71	19.48	-6.63●	28.21	3.51
EV/EBITDA	2.95●	—	14.11	—	—	—	14.82
P/S	12.65	17.66	6.28●	19.23	25.93	13.54	10.89

Financial Health
Metric	IONS	AXSM	EXEL	ARWR	BBIO	MDGL	Ind. Median
Current Ratio	4.10	1.39	3.26	6.23●	1.44	3.50	5.90
Debt/Equity	415.3%	402.8%	8.8%	223.7%	-149.2%●	63.9%	10.9%
NetDebt/EBITDA	0.03	0.49	-0.60	3.06	-4.02●	1.67	1.15

Profitability
Metric	IONS	AXSM	EXEL	ARWR	BBIO	MDGL	Ind. Median
Net Margin	-30.9%	-26.6%	35.1%●	-48.4%	-125.2%	-27.3%	-125.7%
ROE	-67.5%	-349.4%	41.0%●	-46.4%	—	-49.3%	-47.5%
ROA	-10.4%	-28.7%	30.7%●	-15.7%	-64.5%	-27.8%	-35.8%
EBITDA Margin	433.5%●	-24.4%	42.7%	-21.6%	-105.0%	-24.8%	-105.8%

Growth + Dividend
Metric	IONS	AXSM	EXEL	ARWR	BBIO	MDGL	Ind. Median
Rev. Growth	47.5%	63.9%	3.3%	9.4%	355.2%●	256.8%	5.1%
NI Growth	—	—	29.5%	—	—	—	12.1%
Div. Yield	0.2%	—	—	0.3%●	—	—	0.2%
Payout	-6.7%	—	—	-13.8%	—	—	0.0%

The green dot marks the best value in the group given the metric direction (higher/lower is better). All metrics use trailing-twelve-month (TTM) data.

Go deeper on IONS

Run a DCF valuation

Full DCF model with editable assumptions

Start a head-to-head duel

Compare two stocks metric by metric

Filter in the stock screener

Build your own universe with 400+ metrics

Data on this page refreshes once per day. Price data as of Jun 26, 26. This content is for informational purposes only and is not investment advice.