DNLI PEER ANALYSIS

Denali Therapeutics Inc — metric-by-metric comparison with peers and the industry median

DNLIDenali Therapeutics Inc

🇺🇸 USA · NASDAQ · Healthcare · Biotechnology

Value it Duel

Overall Profile & Returns

· Biotechnology

Position Within Industry

0 = weak quartile, 100 = strong quartile

DNLIIndustry median

Scores normalize each metric against industry quartiles (p25–p75); direction is inverted for lower-is-better metrics.

Return Comparison

1-Year

Split-adjusted

Year-to-Date (YTD)

Key Metric Comparison

P/E

Lower is better

ROE

Higher is better

Net Margin

Higher is better

Revenue Growth

Higher is better

All Metrics

Valuation
Metric	DNLI	TLX	MSB	CSL	Ind. Median
P/E	—	—	—	30.02	17.81
P/B	5.19	6.56	—	2.24●	3.49
EV/EBITDA	—	123.31	—	10.37●	14.92
P/S	—	3.34	31.91	2.67●	10.89

Financial Health
Metric	DNLI	TLX	MSB	CSL	Ind. Median
Current Ratio	9.28●	1.43	—	2.57	5.90
Debt/Equity	4.3%●	112.3%	—	67.4%	10.9%
NetDebt/EBITDA	1.92●	13.13	—	2.22	1.15

Profitability
Metric	DNLI	TLX	MSB	CSL	Ind. Median
Net Margin	—	-0.9%	-115.3%	9.2%●	-125.7%
ROE	-49.6%	-1.8%	-11.3%	7.7%●	-47.5%
ROA	-40.0%	-0.7%	-8.6%	3.8%●	-35.8%
EBITDA Margin	—	3.0%	-76.6%	32.8%●	-105.8%

Growth + Dividend
Metric	DNLI	TLX	MSB	CSL	Ind. Median
Rev. Growth	—	56.3%	410.4%●	4.8%	5.1%
NI Growth	—	—	—	-39.4%	12.1%
Div. Yield	—	—	0.0%	2.5%●	0.2%
Payout	—	—	0.0%	103.1%	0.0%

Valuation
Metric	DNLI	ACAD	TVTX	CRNX	VKTX	EWTX	Ind. Median
P/E	—	11.85	—	—	—	—	17.81
P/B	5.19	3.57	53.49	3.42●	8.91	8.71	3.49
EV/EBITDA	—	28.76●	138.66	—	—	—	14.92
P/S	—	4.06●	9.85	242.14	—	—	10.89

Financial Health
Metric	DNLI	ACAD	TVTX	CRNX	VKTX	EWTX	Ind. Median
Current Ratio	9.28	3.59	3.13	18.60	5.72	22.61●	5.90
Debt/Equity	4.3%	4.1%	331.9%	3.7%	—	0.8%●	10.9%
NetDebt/EBITDA	1.92	-6.31●	1.63	2.53	—	2.82	1.15

Profitability
Metric	DNLI	ACAD	TVTX	CRNX	VKTX	EWTX	Ind. Median
Net Margin	—	34.3%●	-4.0%	-2,747.2%	—	—	-125.7%
ROE	-49.6%	37.3%●	-32.6%	-39.2%	-70.0%	-38.1%	-47.5%
ROA	-40.0%	27.4%●	-3.9%	-35.9%	-64.0%	-36.2%	-35.8%
EBITDA Margin	—	11.6%●	7.2%	-2,723.4%	—	—	-105.8%

Growth + Dividend
Metric	DNLI	ACAD	TVTX	CRNX	VKTX	EWTX	Ind. Median
Rev. Growth	—	9.9%	96.0%	2,277.5%●	—	-100.0%	5.1%
NI Growth	—	64.1%	—	—	—	—	12.1%
Div. Yield	—	—	—	—	—	—	0.2%
Payout	—	—	—	—	—	—	0.0%

The green dot marks the best value in the group given the metric direction (higher/lower is better). All metrics use trailing-twelve-month (TTM) data.

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Data on this page refreshes once per day. Price data as of Jul 6, 26. This content is for informational purposes only and is not investment advice.