ANNX PEER ANALYSIS

Annexon Inc — metric-by-metric comparison with peers and the industry median

ANNXAnnexon Inc

🇺🇸 USA · NASDAQ · Healthcare · Biotechnology

Value it Duel

Overall Profile & Returns

· Biotechnology

Position Within Industry

0 = weak quartile, 100 = strong quartile

ANNXIndustry median

Scores normalize each metric against industry quartiles (p25–p75); direction is inverted for lower-is-better metrics.

Return Comparison

1-Year

Split-adjusted

Year-to-Date (YTD)

Key Metric Comparison

P/E

Lower is better

ROE

Higher is better

Net Margin

Higher is better

Revenue Growth

Higher is better

All Metrics

Valuation
Metric	ANNX	MSB	TLX	CSL	RTALB	Ind. Median
P/E	—	—	—	30.02	4.89●	17.81
P/B	5.66	—	6.56	2.24	0.61●	3.49
EV/EBITDA	—	—	123.31	10.37●	74.61	14.92
P/S	—	31.91	3.34	2.67●	6.67	10.89

Financial Health
Metric	ANNX	MSB	TLX	CSL	RTALB	Ind. Median
Current Ratio	6.35●	—	1.43	2.57	1.21	5.90
Debt/Equity	12.4%	—	112.3%	67.4%	1.2%●	10.9%
NetDebt/EBITDA	1.03	—	13.13	2.22	0.90●	1.15

Profitability
Metric	ANNX	MSB	TLX	CSL	RTALB	Ind. Median
Net Margin	—	-115.3%	-0.9%	9.2%	136.3%●	-125.7%
ROE	-87.6%	-11.3%	-1.8%	7.7%	15.1%●	-47.5%
ROA	-69.4%	-8.6%	-0.7%	3.8%	13.1%●	-35.8%
EBITDA Margin	—	-76.6%	3.0%	32.8%●	9.0%	-105.8%

Growth + Dividend
Metric	ANNX	MSB	TLX	CSL	RTALB	Ind. Median
Rev. Growth	-100.0%	410.4%●	56.3%	4.8%	24.0%	5.1%
NI Growth	—	—	—	-39.4%	134.0%●	12.1%
Div. Yield	0.2%	0.0%	—	2.5%●	0.0%	0.2%
Payout	-0.9%	0.0%	—	103.1%	0.0%	0.0%

Valuation
Metric	ANNX	REPL	CGEM	SANA	XNCR	MGTX	Ind. Median
P/E	—	—	—	—	—	—	17.81
P/B	5.66	6.36	2.88	9.22	2.17	-19.43●	3.49
EV/EBITDA	—	—	—	—	—	—	14.92
P/S	—	—	—	—	11.51●	14.16	10.89

Financial Health
Metric	ANNX	REPL	CGEM	SANA	XNCR	MGTX	Ind. Median
Current Ratio	6.35	4.79	10.28●	1.29	6.57	0.55	5.90
Debt/Equity	12.4%	17.0%	0.7%	63.2%	34.0%	-150.6%●	10.9%
NetDebt/EBITDA	1.03	0.77	1.58	0.14	2.05	-0.17●	1.15

Profitability
Metric	ANNX	REPL	CGEM	SANA	XNCR	MGTX	Ind. Median
Net Margin	—	—	—	—	-177.1%	-151.1%●	-125.7%
ROE	-87.6%	-107.9%	-48.2%	-147.4%	-29.8%●	—	-47.5%
ROA	-69.4%	-71.0%	-45.0%	-59.1%	-21.0%●	-51.4%	-35.8%
EBITDA Margin	—	—	—	—	-135.2%	-120.0%●	-105.8%

Growth + Dividend
Metric	ANNX	REPL	CGEM	SANA	XNCR	MGTX	Ind. Median
Rev. Growth	-100.0%	-100.0%	—	-100.0%	-29.2%	131.1%●	5.1%
NI Growth	—	—	—	—	—	—	12.1%
Div. Yield	0.2%	—	—	—	—	—	0.2%
Payout	-0.9%	—	—	—	—	—	0.0%

The green dot marks the best value in the group given the metric direction (higher/lower is better). All metrics use trailing-twelve-month (TTM) data.

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Data on this page refreshes once per day. Price data as of Jul 6, 26. This content is for informational purposes only and is not investment advice.